Antibody subclass deficiency accelerates tumorigenesis in genetically engineered mouse models of pancreatic cancer
Jeremy B Foote, Sujith Sarvesh, Sameer Al Diffalha, David K Crossman, Changde Cheng, Myung-Hee Kim, Cherlene Hardy, Julienne L Carstens, Kyoko Kojima, Bart J Rose, Christopher A Klug · 2026
Read Antibody subclass deficiency accelerates tumorigenesis in genetically engineered mouse models of pancreatic cancer by Jeremy B Foote, Sujith Sarvesh, Sameer Al Diffalha, David K Crossman, Changde Cheng, Myung-Hee Kim, Cherlene Hardy, Julienne L Carstens, Kyoko Kojima, Bart J Rose, Christopher A Klug (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-13460815.txt.
Description
Jeremy Foote and co-authors study how missing antibodies affect pancreatic cancer growth in mice in this 2026 paper. Antibodies from B cells can help or hinder the fight against tumors. Their role while this cancer forms had not been tested directly.
The team crossed a standard cancer-prone mouse strain with mice that make no circulating antibodies. The crossed mice formed tumors twice as fast and lived about half as long, with more spread to the liver. Their tumors held fewer defender T cells and more suppressive cells. The tissue scaffold around tumors was also thinner in the no-antibody mice. A second cross lacking only some antibody types matched the pattern, pointing to one class as a brake on this cancer.
Catalog record
| CREATOR | Jeremy B Foote, Sujith Sarvesh, Sameer Al Diffalha, David K Crossman, Changde Cheng, Myung-Hee Kim, Cherlene Hardy, Julienne L Carstens, Kyoko Kojima, Bart J Rose, Christopher A Klug |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 55 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |