Hexokinase-3 upregulation and histone H3K18 lactylation mediate murine liver fibrosis induced by Echinococcus multilocularis
Yurun Miao, Lixian Shan, Jing Liu, Wei Cui, Xiangyang Yang, Lei Xiu, Wenbin Yang, Chunfu Li, Wenhui Liu, Yan Wang, Ting Zhang, Wei Hu · 2026
Read Hexokinase-3 upregulation and histone H3K18 lactylation mediate murine liver fibrosis induced by Echinococcus multilocularis by Yurun Miao, Lixian Shan, Jing Liu, Wei Cui, Xiangyang Yang, Lei Xiu, Wenbin Yang, Chunfu Li, Wenhui Liu, Yan Wang, Ting Zhang, Wei Hu (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/PMC13460742.txt.
Description
Miao and colleagues traced in 2026 how a tapeworm infection scars the liver, linking the damage to a sugar-burning enzyme and a chemical tag on DNA packaging proteins. Alveolar echinococcosis, caused by the fox tapeworm, grows through the liver and stiffens it with scar tissue. The tag, called lactylation, comes from lactate, a by-product of fast sugar burning, and had been tied to scarring in other settings.
In infected mice, lactate ran high in liver and blood, and one enzyme, hexokinase-3, rose sharply. The tagged form of a packaging protein sat on scar-related genes in infected livers. In liver cells exposed to worm products, silencing the enzyme cut both the tagging and scar proteins. Adding lactate restored them even without the enzyme. The authors name the enzyme as a drug target for this neglected disease.
Catalog record
| CREATOR | Yurun Miao, Lixian Shan, Jing Liu, Wei Cui, Xiangyang Yang, Lei Xiu, Wenbin Yang, Chunfu Li, Wenhui Liu, Yan Wang, Ting Zhang, Wei Hu |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 56 KB |
| LICENSE | https://creativecommons.org/licenses/by/4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |