A layered target-release nanoparticle system for normalizing the lung cancer microenvironment and enhancing antitumor effect
Linjia Zhu, Xiaoqiang Chen, Dong Chun, Qiuyan Lin, Shaofei Yuan · 2026
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Description
Linjia Zhu, Xiaoqiang Chen, Dong Chun, Qiuyan Lin, and Shaofei Yuan designed in 2026 a layered nanoparticle that first loosens the lung tumor's surroundings and then attacks the cancer cells. Solid tumors grow abnormal vessels and dense collagen, raising internal pressure and blocking drug carriers. Their two-layer particle responds to acidity: the outer layer releases ligustrazine, while the inner core carries triptolide inside a folic acid tagged shell that tumor cells take up readily.
In the acidic tumor setting, the outer agent released first and lowered internal pressure, letting particles penetrate deeper. The inner particles then entered lung cancer cells efficiently and delivered their payload. Cell experiments and characterization supported the staged design. Animal evaluation in thoracic tumor models is the stated next step for this barrier-breaking strategy.
Catalog record
| CREATOR | Linjia Zhu, Xiaoqiang Chen, Dong Chun, Qiuyan Lin, Shaofei Yuan |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 38 KB |
| LICENSE | https://creativecommons.org/licenses/by/4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |