The landscape of protein post-translational modifications in the pathogenesis of acute respiratory distress syndrome
Haikun Zhang, Jinxiang Yu, Pengcheng Ma, Lifeng Jia, Le Cao, Nianliang Zhang, Gang Li, Tao Zhao · 2026
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Description
Haikun Zhang and co-authors survey in 2026 how protein post-translational modifications, chemical edits made to proteins after they are built, drive acute respiratory distress syndrome. This catastrophic lung failure floods the air sacs and resists drug treatment, so attention turns to fast molecular switches. Classic edits such as phosphorylation and ubiquitination are covered first, as coordinators of the cytokine storm, vessel leakage, and failed fluid clearance.
Newer modifications then take the stage, including citrullination and lactylation, tied to neutrophil traps and amplifying inflammation. The review argues that the injured lung's rewired metabolism controls the enzymes performing these edits, making metabolism an upstream lever. Crosstalk between modifications and drugs targeting their enzymes close the discussion, with multi-omics studies proposed to bridge laboratory and bedside.
Catalog record
| CREATOR | Haikun Zhang, Jinxiang Yu, Pengcheng Ma, Lifeng Jia, Le Cao, Nianliang Zhang, Gang Li, Tao Zhao |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 52835 |
| LICENSE | https://creativecommons.org/licenses/by/4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |