Pathological or preventative? Amyloid-β as an effector of innate immunity
Oluwagbenro O. Adesunloro, Amanda N. Tuckey, Jonathon P. Audia, Allyson E. Shea · 2026
Read Pathological or preventative? Amyloid-β as an effector of innate immunity by Oluwagbenro O. Adesunloro, Amanda N. Tuckey, Jonathon P. Audia, Allyson E. Shea (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/PMC13459691.txt.
Description
Oluwagbenro O. Adesunloro, Amanda N. Tuckey, Jonathon P. Audia, and Allyson E. Shea argue in a 2026 minireview that amyloid-beta, the protein fragment infamous in Alzheimer disease, may also defend the brain against infection. Plaques built from this fragment have long been read purely as damage. Evidence from clinical reports, animal work, and laboratory studies instead suggests the fragment is produced when microbes invade.
Acting much like an antimicrobial peptide, amyloid-beta can disrupt microbial membranes and trap invaders, while also sending inflammatory signals that rally immune defense. The reviewers gather this evidence to broaden how the molecule is understood. Their framing raises a delicate question for Alzheimer research: blocking a defense molecule could carry costs alongside any benefit.
Catalog record
| CREATOR | Oluwagbenro O. Adesunloro, Amanda N. Tuckey, Jonathon P. Audia, Allyson E. Shea |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 34515 |
| LICENSE | https://creativecommons.org/licenses/by/4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |