Identification of PANoptosis-related hub genes in acute myocardial infarction: diagnostic potential, immune correlates, and therapeutic insights
Xuebing Wang, Xunli Yin, Linlin Teng, Dong Tao · 2026
Read Identification of PANoptosis-related hub genes in acute myocardial infarction: diagnostic potential, immune correlates, and therapeutic insights by Xuebing Wang, Xunli Yin, Linlin Teng, Dong Tao (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/PMC13459456.txt.
Description
Xuebing Wang, Xunli Yin, Linlin Teng, and Dong Tao searched in 2026 for genes linked to PANoptosis that could help diagnose acute myocardial infarction, a heart attack. PANoptosis blends features of three cell-death pathways and drives inflammation. The team mined public gene-expression datasets to compare heart attack patients with controls. Network building and random forest modeling then narrowed hundreds of altered genes down to candidates. Findings were checked in patient blood samples.
Two genes, IL1B and NLRP3, emerged as hubs, and diagnostic models built on them performed well in both training and validation sets. Both genes tracked closely with immune cells that shift during a heart attack, and two shared regulators were identified. Five candidate drugs tied to the genes were also predicted, offering starting points for treatment research.
Catalog record
| CREATOR | Xuebing Wang, Xunli Yin, Linlin Teng, Dong Tao |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 40242 |
| LICENSE | https://creativecommons.org/licenses/by/4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |