Role of sarcopenia, obesity and sarcopenic obesity in frailty, frailty transitions and death
Alejandro Álvarez-Bustos, Jose A Carnicero, Walter Sepúlveda-Loyola, Francisco J Garcia-Garcia, Leocadio Rodríguez-Mañas · 2026
Read Role of sarcopenia, obesity and sarcopenic obesity in frailty, frailty transitions and death by Alejandro Álvarez-Bustos, Jose A Carnicero, Walter Sepúlveda-Loyola, Francisco J Garcia-Garcia, Leocadio Rodríguez-Mañas (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-13459406.txt.
Description
Alejandro Álvarez-Bustos and colleagues examine how muscle loss, heavy weight and their pairing shape frailty change and death in a 2026 cohort study. Muscle loss with heavy weight had been largely ignored in frailty shifts, despite both conditions predicting daily-life decline. The look-back cohort covered 1,538 home-living adults aged 65 and older, with frailty scored by two scales and follow-up medians of 2.99 years for shifts and 6.29 years for death.
Muscle loss with heavy weight always predicted frailty decline and lowered the chance of undoing early frailty, while muscle loss alone and heavy weight alone also raised decline rates. No group predicted death on its own once frailty status was counted in. Doctors gain a clearer target: keeping muscle and watching weight together may slow daily-life decline, even if death risk tracks frailty itself.
Catalog record
| CREATOR | Alejandro Álvarez-Bustos, Jose A Carnicero, Walter Sepúlveda-Loyola, Francisco J Garcia-Garcia, Leocadio Rodríguez-Mañas |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 39 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |