Mycobacterium bovis induces cellular oxidative stress via the host protein SH3PXD2B
Donghui Liu, Ting Zhang, Zhengzhong Xu, Chengkun Zheng, Xin’an Jiao, Xiang Chen · 2026
Read Mycobacterium bovis induces cellular oxidative stress via the host protein SH3PXD2B by Donghui Liu, Ting Zhang, Zhengzhong Xu, Chengkun Zheng, Xin’an Jiao, Xiang Chen (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-13459242.txt.
Description
Donghui Liu and colleagues show how bovine TB germs turn a host protein against the body to cause oxygen damage in a 2026 study. Mycobacterium bovis spreads by aerosol, settles in lungs and stresses guard cells, yet the host route behind oxygen injury was unclear. The team tracked SH3PXD2B during infection, testing extra copies and knockdown effects on harmful oxygen species, fat harm and shields.
Infection raised SH3PXD2B, which boosted NOX-dependent harmful oxygen species and the fat-harm marker MDA, while muting the Nrf2 defence pathway and key defence enzymes. Knockdown reversed those effects and improved cell survival. SH3PXD2B thus both raises harmful oxygen and cripples shields, marking it as a target for cattle disease toughness and new cures.
Catalog record
| CREATOR | Donghui Liu, Ting Zhang, Zhengzhong Xu, Chengkun Zheng, Xin’an Jiao, Xiang Chen |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 36 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |