Bacterial EPIYA/EPIYA-like effector motifs and host regulatory pY-SH2 logic: a sequence-informed three-layer convergence model
Chunyan Wang, Congli Yuan · 2026
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Description
Chunyan Wang and Congli Yuan propose a fresh lens for how bacterial weapons plug into human cell signaling. Many pathogens inject effector proteins carrying EPIYA motifs; host enzymes phosphorylate them, and host SH2-domain proteins then dock and reroute the cell. Their 2026 perspective builds a sequence-informed, three-layer convergence model comparing the bacterial motifs with the host's braking signals, ITIM and ITSM.
Convergence, they argue, happens at three levels: the sequence grammar around the tyrosine, compatibility with host kinases writing the mark, and recognition by SH2 readers interpreting it. Effectors such as Helicobacter's CagA, Bartonella's BepD, and E. coli's Tir show pathogens installing look-alike docking sites without copying host motifs; a logo-based comparison makes the pattern visible. The authors stress this is analogy, not homology. Their framework shifts attention to whether host machinery can write and read a motif, a prediction tool for new effectors.
Catalog record
| CREATOR | Chunyan Wang, Congli Yuan |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 21 KB |
| LICENSE | https://creativecommons.org/licenses/by/4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |