Visible Light-Induced Intermolecular Dearomatization for Constructing Angularly Fused Tetracyclic Scaffolds
Fan Lin, Ting-Ting Song, Li-Ming Zhang, Zhi-Yuan Ding, Yilitabaier Julaiti, Yanhua Lu, Boshun Wan, Yaguang Sun, Qing-An Chen · 2026
Read Visible Light-Induced Intermolecular Dearomatization for Constructing Angularly Fused Tetracyclic Scaffolds by Fan Lin, Ting-Ting Song, Li-Ming Zhang, Zhi-Yuan Ding, Yilitabaier Julaiti, Yanhua Lu, Boshun Wan, Yaguang Sun, Qing-An Chen (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/PMC13457606.txt.
Description
Fan Lin and colleagues shine visible light on a shortcut to complex four-ring molecular structures. Angularly fused tetracyclic cores appear in prized natural products and drug candidates, yet building them takes long sequences. Their 2026 chemistry paper pairs benzothiophene or indole starting materials with N-aryl cyclopropylamines under photocatalysis, breaking open the aromatic ring's flat, stable form in a controlled dearomatization.
The reaction runs as a cascade: a light-driven [3+2] cycloaddition between the two partners, followed by a ring-closing step that locks the angular fusion in place. Earlier dearomative tricks worked within a single molecule; doing the key bond-making between two distinct molecules widens the menu of reachable scaffolds a lot. The authors present the protocol as robust and direct, giving synthetic chemists a shorter route into strained frameworks with real three-dimensional depth that medicinal chemistry prizes. The work spans photocatalysis, homogeneous catalysis, and synthetic methods.
Catalog record
| CREATOR | Fan Lin, Ting-Ting Song, Li-Ming Zhang, Zhi-Yuan Ding, Yilitabaier Julaiti, Yanhua Lu, Boshun Wan, Yaguang Sun, Qing-An Chen |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 33782 |
| LICENSE | https://creativecommons.org/licenses/by/4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |