Interferon-gamma to interleukin-10 ratio is negatively associated with short-term mortality risk in sepsis patients: a retrospective study based on immune balance index
Mingyuan Pan, Wenhui Huang, Yuyang Li, Hongsheng Lu, Xiao Teng, Zheng Li · 2026
Read Interferon-gamma to interleukin-10 ratio is negatively associated with short-term mortality risk in sepsis patients: a retrospective study based on immune balance index by Mingyuan Pan, Wenhui Huang, Yuyang Li, Hongsheng Lu, Xiao Teng, Zheng Li (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/PMC13457149.txt.
Description
Mingyuan Pan and colleagues report a 2026 retrospective study of whether an immune balance measure can predict short-term death in sepsis. Their index divides interferon-gamma, a signal that drives inflammation, by interleukin-10, a signal that calms it. The team drew records for 411 sepsis patients treated in one intensive care unit at the Second Affiliated Hospital of Guangxi Medical University between December 2023 and January 2026.
Patients were grouped by their first ratio value within a day of admission, and survival was tracked at 14 and 28 days. Higher ratios went with clearly lower death rates at both points, and the link held after adjustment for other factors, with hazard ratios near 0.48 and a similar 0.62 for the highest group. The relationship was curved rather than straight, with turning points near 0.07. The authors suggest the ratio could help flag which sepsis patients face the greatest early risk.
Catalog record
| CREATOR | Mingyuan Pan, Wenhui Huang, Yuyang Li, Hongsheng Lu, Xiao Teng, Zheng Li |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 40 KB |
| LICENSE | https://creativecommons.org/licenses/by/4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |