The Relationship Between Obesity and Intestinal Alkaline Phosphatase: A Clinical and Biochemical Study
Alper Uysal, Nilay Danış, Ali Şenkaya, Seymur Aslanov, Ilgın Yıldız Şimşir, Güliz Armağan, Rukiye Vardar · 2026
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Description
Alper Uysal and colleagues examined whether an enzyme made in the gut lining, intestinal alkaline phosphatase, runs lower in people with obesity. The enzyme helps guard the gut barrier and calm inflammation, but human data on it were scarce. In their 2026 study, 52 adults having a diagnostic upper endoscopy gave blood samples and small duodenal tissue samples, which the team measured with standard laboratory assays and protein blotting.
Both blood and tissue levels of the enzyme fell as body mass index rose, showing strong inverse correlations with weight and waist size. Adults with obesity had significantly lower levels than normal-weight participants, and tissue levels were also lower in people with metabolic syndrome, a cluster of risk factors for diabetes and heart disease. The authors suggest the enzyme could serve as a marker of obesity-related metabolic problems.
Catalog record
| CREATOR | Alper Uysal, Nilay Danış, Ali Şenkaya, Seymur Aslanov, Ilgın Yıldız Şimşir, Güliz Armağan, Rukiye Vardar |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 28 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |