Dysregulation of liquid-liquid phase separation: from molecular mechanisms to targeted therapies in cardiovascular diseases
Xiaoyu Zhang, Xuejuan Ma, Ning Cao, Yuan Zhou, Zhigang Zhang, Runwei Ma · 2026
Read Dysregulation of liquid-liquid phase separation: from molecular mechanisms to targeted therapies in cardiovascular diseases by Xiaoyu Zhang, Xuejuan Ma, Ning Cao, Yuan Zhou, Zhigang Zhang, Runwei Ma (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-13455351.txt.
Description
Xiaoyu Zhang and colleagues review how droplets inside cells go wrong in heart disease in a 2026 paper. Cells form blob-like compartments without membranes through a process called liquid-liquid phase separation, and when those blobs harden or misbehave, heart muscle can suffer. The review gathers evidence across heart conditions and proposes a shared thread: chemical marks on RNA, called m6A, working with flexible proteins to steer blob formation.
The authors argue that a shift from liquid blobs to gel or solid clumps may lock in late-stage heart damage, and that RNA marks plus protein marks act together on that axis. Four treatment paths are surveyed, including small molecules, delivery materials, chiral nanomaterials and targeting protein marks. The framework is a hypothesis to test, not a proven therapy, but it gives heart researchers one axis to probe across many diseases.
Catalog record
| CREATOR | Xiaoyu Zhang, Xuejuan Ma, Ning Cao, Yuan Zhou, Zhigang Zhang, Runwei Ma |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 83 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |