Blood-based biomarkers for early diagnosis of Alzheimer’s disease: a current systematic review of diagnostic accuracy studies
Jaiyeoba-Ojigho Jennifer Efe, Ese Anibor, Priyanka Pandey, Oladipo Gabriel Sunday, David Chinaecherem Innocent, Precious Ebube Anyakorah, Okolie Ikechukwu Emmanuel · 2026
Read Blood-based biomarkers for early diagnosis of Alzheimer’s disease: a current systematic review of diagnostic accuracy studies by Jaiyeoba-Ojigho Jennifer Efe, Ese Anibor, Priyanka Pandey, Oladipo Gabriel Sunday, David Chinaecherem Innocent, Precious Ebube Anyakorah, Okolie Ikechukwu Emmanuel (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-13455272.txt.
Description
Jaiyeoba-Ojigho and team reviewed accuracy studies of blood tests for early Alzheimer's disease. Such tests are an appealing alternative to costly brain scans and needle-based spinal fluid sampling. Searching five databases for studies from 2010 to March 2026 under standard review rules left just six qualifying accuracy studies.
Phosphorylated tau markers did most consistently, with p-tau181 and p-tau217 reaching areas under the curve up to 0.93 for detecting Alzheimer's pathology in the included studies. The glial marker GFAP also did strongly at up to 0.87, while amyloid ratios ranged widely from 0.69 to 0.94 across different commercial assays tested. Neurofilament light chain topped out at 0.79 and predicted progression better than early presence of disease in the review's synthesis. Combinations, especially adding APOE genetic status, beat single markers, reaching 0.92 in the best-performing panels.
Catalog record
| CREATOR | Jaiyeoba-Ojigho Jennifer Efe, Ese Anibor, Priyanka Pandey, Oladipo Gabriel Sunday, David Chinaecherem Innocent, Precious Ebube Anyakorah, Okolie Ikechukwu Emmanuel |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 57 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |