Integrated analysis of miRNA and transcription factor gene expression profiles associated with anti-tuberculosis treatment responses

Description

Heechul Park and colleagues report a 2026 study of blood signals that shift as people are treated for active tuberculosis. The lung disease still kills many people each year, and doctors lack a simple blood test that shows whether drugs are working, above all when sputum tests fail or labs are scarce. Twelve patients gave blood before and after treatment, and a second set of 22 samples served to check the main signals.

After six months of drugs, nine small RNA molecules had moved back toward levels seen in healthy people, and all nine fell by the end of therapy in the check set. Sequencing of longer RNA from the same blood found 75 changed messages, with 13 tied to those small RNAs through a target search tool. The authors present the nine molecules as possible markers for tracking drug response, though larger and more varied groups must test them first.

Catalog record

Source: https://europepmc.org/articles/PMC13455268