Dexpramipexole alleviates chronic allodynia from sciatic neuropathy and reduces spinal interferon-γ and other proinflammatory cytokines in spinal cord and dorsal root ganglia in mice
Noah A. Castro, Clara J. Tomicek, Melody S. Sun, Justine R. Zimmerly, Annette K. Fernandez-Oropeza, Sammy D. Gomez-Medina, Zarena M. Dominguez, Shahani Noor, Jessie R. Maxwell, Erin D. Milligan · 2026
Read Dexpramipexole alleviates chronic allodynia from sciatic neuropathy and reduces spinal interferon-γ and other proinflammatory cytokines in spinal cord and dorsal root ganglia in mice by Noah A. Castro, Clara J. Tomicek, Melody S. Sun, Justine R. Zimmerly, Annette K. Fernandez-Oropeza, Sammy D. Gomez-Medina, Zarena M. Dominguez, Shahani Noor, Jessie R. Maxwell, Erin D. Milligan (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-13455235.txt.
Description
Noah A. Castro and others showed in 2026 that dexpramipexole eases long-term allodynia from sciatic nerve harm and cuts spine swelling cytokines in mice. Dexpramipexole blocks the Nav1.8 sodium gate on pain nerves and calms immune cells, with past wins in eosinophilic asthma trials and preclinical nerve-harm models. The new study ran full time courses of body-wide and spine dexpramipexole on set allodynia from chronic constriction harm.
Body and spine drug runs were tested for light-touch pain, with spine cord and dorsal root ganglia cytokines charted. Pain signs read in limbic brain zones steer stress through hypothalamic sympathetic drive that wakes spleen and adrenal glands, which link pain, stress, and immunity. The work shows dexpramipexole cuts allodynia and spine interferon-gamma and other flare cytokines. Pain teams gain a two-action lead for nerve pain.
Catalog record
| CREATOR | Noah A. Castro, Clara J. Tomicek, Melody S. Sun, Justine R. Zimmerly, Annette K. Fernandez-Oropeza, Sammy D. Gomez-Medina, Zarena M. Dominguez, Shahani Noor, Jessie R. Maxwell, Erin D. Milligan |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 49 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |