Dose–response relationship of early out-of-bed mobilization with functional decline and adverse events in patients after cardiovascular surgery requiring prolonged intensive care: a retrospective cohort study

Description

Hirakawa and team asked how much early out-of-bed activity protects heart surgery patients stuck in intensive care for three days or more from losing independence by discharge. Their retrospective cohort covered 610 such patients, with mobilization dose tallied in 20-minute units of standing-level activity per day.

After matching 196 low-dose patients against 196 high-dose patients on baseline characteristics, functional decline struck 31.6 percent of the low-dose group versus 19.9 percent of the high-dose group at discharge. That gap translated to an odds ratio of 2.03 for decline with low mobilization in the matched analysis. Adverse events during mobilization were rare at 1.2 percent overall and did not differ significantly between dose groups in the safety comparison. Spline modeling showed a nonlinear dose-response curve, supporting a threshold message: reach an adequate daily dose and function is preserved without added risk.

Catalog record

Source: https://europepmc.org/articles/PMC13455185