pH sensing and inflammation: linking acidic microenvironments to immune reprogramming
Mingyu Zhang, Jiaju Tian, Weiming Sun · 2026
Read pH sensing and inflammation: linking acidic microenvironments to immune reprogramming by Mingyu Zhang, Jiaju Tian, Weiming Sun (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/PMC13455001.txt.
Description
Mingyu Zhang, Jiaju Tian, and Weiming Sun review, in 2026, how the immune system senses acidity and turns it into inflammatory action. Acidity was once viewed as a mere waste product of metabolism. Inflamed, infected, and tumor tissues all turn acidic, and immune cells carry dedicated proton sensors on their surfaces.
The review sorts the sensors into families: surface receptors such as GPR4 and GPR68, acid-gated channels, and inside-cell factors that read pH shifts. Each converts a sour environment into signals that reshape gene activity and cell behavior. The authors map how these routes plug into the wider inflammation network. They close with prospects for sourness-based diagnostic markers and drugs that tune the sensors. Their larger claim is that pH deserves treatment as a true immune signal, not background noise.
Catalog record
| CREATOR | Mingyu Zhang, Jiaju Tian, Weiming Sun |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 66 KB |
| LICENSE | https://creativecommons.org/licenses/by/4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |