Mitochondria Dictate Progressive Versus Bimodal Aging of the Mammary Gland
Edmund Charles Jenkins, Mrittika Chattopadhyay, Thelma Mashaka, Miguel Torres‐Martin, Daniela Sia, Igor Bado, Doris Germain · 2026
Read Mitochondria Dictate Progressive Versus Bimodal Aging of the Mammary Gland by Edmund Charles Jenkins, Mrittika Chattopadhyay, Thelma Mashaka, Miguel Torres‐Martin, Daniela Sia, Igor Bado, Doris Germain (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/PMC13454215.txt.
Description
Jenkins and colleagues ask why breast cancer peaks twice, near ages 45 and 65, and whether the way the breast ages helps explain it. Their 2026 study uses two mouse models of mammary gland aging, the tissue that becomes the breast. One model ages in a steady, step by step way. The other ages in waves, and the team compares gene and protein activity plus cancer cell growth across the animals' lives.
In the wave model, cancer linked genes and proteins rose at 11 and 19 months but not at 3 or 14 months of mouse age. Glands at those peak ages also let cancer cells grow more readily, while the steady model grew more permissive only after 14 months. A gene signature from the wave pattern, built from single cell data, was enriched in women diagnosed at ages 45 to 65, matching the mouse ages.
Catalog record
| CREATOR | Edmund Charles Jenkins, Mrittika Chattopadhyay, Thelma Mashaka, Miguel Torres‐Martin, Daniela Sia, Igor Bado, Doris Germain |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 55 KB |
| LICENSE | https://creativecommons.org/licenses/by/4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |