Effects of fluoroquinolone antibiotics on extracellular matrix-related phenotypes in tendon cells
Akshay Anand, Keiko Sakai, David Dickens, Sadatoshi Tsuzuki, Sachiko Minamiguchi, Naoya Asai, Ahmed Kazaili, Riaz Akhtar, Munir Pirmohamed, Takao Sakai · 2026
Read Effects of fluoroquinolone antibiotics on extracellular matrix-related phenotypes in tendon cells by Akshay Anand, Keiko Sakai, David Dickens, Sadatoshi Tsuzuki, Sachiko Minamiguchi, Naoya Asai, Ahmed Kazaili, Riaz Akhtar, Munir Pirmohamed, Takao Sakai (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-13454159.txt.
Description
Akshay Anand and others showed in 2026 how fluoroquinolone drugs harm tendon cells by wrecking their matrix. These drugs are much used for their gut uptake and wide kill range, but they can rarely cause grave tendon ills, such as tendinopathy. How tendon-made matrix shifts in reply was not clearly framed.
Mouse tendon cells took up ciprofloxacin by carrier haul in dish tests. The drug cut type-one collagen make, build skill, and hydroxyproline share, with less fibronectin make too. Lysyl oxidase work fell, and collagen threads grew less stiff and thinner, with less active beta-one integrin, the key matrix dock. Doctors gain a clear tale for drug-linked tendon harm.
Catalog record
| CREATOR | Akshay Anand, Keiko Sakai, David Dickens, Sadatoshi Tsuzuki, Sachiko Minamiguchi, Naoya Asai, Ahmed Kazaili, Riaz Akhtar, Munir Pirmohamed, Takao Sakai |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 39 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |