Disruption of the reciprocal inhibitory relationship between cell proliferation and melanogenesis in pet murine melanoma cells by ultraviolet radiation
Quanzhou Lv, Enchang Liang, Liangshuo Bai, Siqi Huang, Jiran Song, Hui Yin, Yan Li · 2026
Read Disruption of the reciprocal inhibitory relationship between cell proliferation and melanogenesis in pet murine melanoma cells by ultraviolet radiation by Quanzhou Lv, Enchang Liang, Liangshuo Bai, Siqi Huang, Jiran Song, Hui Yin, Yan Li (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/PMC13454102.txt.
Description
Quanzhou Lv and six co-authors probe how ultraviolet light changes the balance between pigment making and growth in melanoma cells from pet mice. In healthy skin, making melanin and dividing pull against each other. Their 2026 study exposes a mouse melanoma cell line to UV doses up to 2,880 joules per square metre, then measures both the dark pigment eumelanin and cell growth.
At low to moderate doses, pigment and growth rose together in a straight line link. At the highest dose that link broke down. A protein network analysis pointed to PIAS3, a regulator that touches two master switches of melanoma, as a possible hinge. The authors read UV as a double agent: it triggers pigment as a shield at mild doses while also feeding tumor growth, until overload breaks the pattern.
Catalog record
| CREATOR | Quanzhou Lv, Enchang Liang, Liangshuo Bai, Siqi Huang, Jiran Song, Hui Yin, Yan Li |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 24 KB |
| LICENSE | https://creativecommons.org/licenses/by/4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |