Mitochondrial respiration and nucleotide profiling in human left internal mammary artery from CABG: a novel real-time ex vivo approach
Alicja Braczko, Andrzej Łoś, Marta Piotrowska, Ada Kawecka, Iga Walczak, Mikołaj Krysiak, Marcin Hellmann, Maciej Brzeziński, Ryszard T. Smoleński, Barbara Kutryb-Zając · 2026
Read Mitochondrial respiration and nucleotide profiling in human left internal mammary artery from CABG: a novel real-time ex vivo approach by Alicja Braczko, Andrzej Łoś, Marta Piotrowska, Ada Kawecka, Iga Walczak, Mikołaj Krysiak, Marcin Hellmann, Maciej Brzeziński, Ryszard T. Smoleński, Barbara Kutryb-Zając (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/PMC13453951.txt.
Description
Alicja Braczko and nine co-authors show a way to watch mitochondria breathe in a piece of living human artery, in real time. The tissue is the left internal mammary artery, a vessel often borrowed for heart bypass grafts. Their 2026 study takes segments during bypass surgery and tests them on a Seahorse analyzer, a bench tool that tracks oxygen use.
A standard stress test read out the artery's base and peak breathing rates while the tissue stayed intact. In parallel, a liquid separation method measured the tissue's energy carrying nucleotides, which report on energy status and redox balance. Pairing the two reads gave a fuller picture of the graft's energy health than either alone. The authors present the workflow as a first for intact human vessel tissue and a base for vessel metabolism studies.
Catalog record
| CREATOR | Alicja Braczko, Andrzej Łoś, Marta Piotrowska, Ada Kawecka, Iga Walczak, Mikołaj Krysiak, Marcin Hellmann, Maciej Brzeziński, Ryszard T. Smoleński, Barbara Kutryb-Zając |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 16 KB |
| LICENSE | https://creativecommons.org/licenses/by/4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |