Adjudicating Heart Failure as an End Point in Dialysis Trials: More Signal, Less Noise
Emma O’Lone, Patrick B. Mark · 2026
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Description
Emma O'Lone and Patrick B Mark argue that heart failure events in dialysis trials need sharper, shared judging rules. Their 2026 commentary notes that heart failure itself has grown harder to pin down, with guidelines now splitting it by ejection fraction, the share of blood the heart pumps out. Major kidney trials have each defined a hospital stay for heart failure in their own way.
The piece lines up those rival definitions side by side, covering symptoms, blood markers, and scan findings that trials require. Some trials demand a stay of 24 hours plus hard proof, while others set lower or different bars. Such drift adds noise that can hide a real treatment effect or fake one. The authors push for careful event judging, called adjudication, so dialysis trials give a cleaner signal for patients and doctors.
Catalog record
| CREATOR | Emma O’Lone, Patrick B. Mark |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 16162 |
| LICENSE | https://creativecommons.org/licenses/by/4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |