Y-RBCEVs accelerate fracture repair through osteogenesis and VCAN-mediated CD44/PI3K/AKT-dependent macrophage polarization
Jiahao Wang, Xiaokang Zhang, Qi Zhang, Jiheng Xiao, Siteng Li, Jianpeng Chen, Chengbin Huang, Yang Luo, Zeming Shan, Ziping Chen, Ling Wang, Yingze Zhang · 2026
Read Y-RBCEVs accelerate fracture repair through osteogenesis and VCAN-mediated CD44/PI3K/AKT-dependent macrophage polarization by Jiahao Wang, Xiaokang Zhang, Qi Zhang, Jiheng Xiao, Siteng Li, Jianpeng Chen, Chengbin Huang, Yang Luo, Zeming Shan, Ziping Chen, Ling Wang, Yingze Zhang (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/PMC13452366.txt.
Description
Wang and colleagues tested in 2026 whether tiny vesicles shed by young red blood cells can speed bone healing. Vesicles are small parcels that cells release to pass signals to neighbors. The team noticed in health survey data that red cell measures tracked with bone density and survival after fractures, which hinted the parcels might help repair.
In lab dishes, vesicles from young red cells entered bone-forming cells and boosted their bone-building activity. They also nudged macrophages, immune cells at the injury site, toward a healing state, partly rescuing stalled bone growth. In mice with leg fractures, the vesicles gathered at the break and improved regrowth without visible harm. Protein sorting fingered a cargo called VCAN, which docks onto macrophages and switches on a growth pathway.
Catalog record
| CREATOR | Jiahao Wang, Xiaokang Zhang, Qi Zhang, Jiheng Xiao, Siteng Li, Jianpeng Chen, Chengbin Huang, Yang Luo, Zeming Shan, Ziping Chen, Ling Wang, Yingze Zhang |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 75 KB |
| LICENSE | https://creativecommons.org/licenses/by/4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |