Skeletal muscle reprogramming of metabolic, ribosomal and developmental pathways contributes to Roux-en-Y gastric bypass-induced adaptation in women
Chantal A. Pileggi, Dhanuddara Mohottalage, Luke S. Kennedy, Majid Nikpay, Lauren M.K. Hamilton, Martín Roffe, Michel N. Kanaan, Amer Jarrar, Nicole Kolozsvari, Dongdong Wang, Miroslava Cuperlovic-Culf, Tommy Alain, Gregory R. Steinberg, Ruth McPherson, Robert Dent, Mary-Ellen Harper · 2026
Read Skeletal muscle reprogramming of metabolic, ribosomal and developmental pathways contributes to Roux-en-Y gastric bypass-induced adaptation in women by Chantal A. Pileggi, Dhanuddara Mohottalage, Luke S. Kennedy, Majid Nikpay, Lauren M.K. Hamilton, Martín Roffe, Michel N. Kanaan, Amer Jarrar, Nicole Kolozsvari, Dongdong Wang, Miroslava Cuperlovic-Culf, Tommy Alain, Gregory R. Steinberg, Ruth McPherson, Robert Dent, Mary-Ellen Harper (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/PMC13452326.txt.
Description
Pileggi and colleagues published a 2026 study on how stomach bypass surgery rewires women's muscles. Roux-en-Y bypass shrinks the stomach and reroutes food to aid weight loss. The team tracked 41 women before surgery and one year afterward. They read gene tags and gene activity in thigh muscle samples.
Over 8,000 gene regions changed their chemical tags after the surgery. More than 2,000 genes also changed how strongly they switched on. Muscle-building and protein-making genes turned up, aiding strength and repair. Energy-factory genes eased down even as those factories grew in number. Pre-surgery muscle traits partly predicted who lost the most weight. Weight loss and fat loss were marked across the full group. Muscle samples came from the thigh muscle of each participant studied.
Catalog record
| CREATOR | Chantal A. Pileggi, Dhanuddara Mohottalage, Luke S. Kennedy, Majid Nikpay, Lauren M.K. Hamilton, Martín Roffe, Michel N. Kanaan, Amer Jarrar, Nicole Kolozsvari, Dongdong Wang, Miroslava Cuperlovic-Culf, Tommy Alain, Gregory R. Steinberg, Ruth McPherson, Robert Dent, Mary-Ellen Harper |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 88 KB |
| LICENSE | https://creativecommons.org/licenses/by/4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |