Ketamine preserves perineuronal nets in chronic stressed mice brain through the inhibition of microglia activation
Jingwen Yang, Ting Huang, Meng Wang, Yingrui Xu, Xuan Li, Changqi Li, Wenyu Cao, Liyan He, Huamao Zhou · 2026
Read Ketamine preserves perineuronal nets in chronic stressed mice brain through the inhibition of microglia activation by Jingwen Yang, Ting Huang, Meng Wang, Yingrui Xu, Xuan Li, Changqi Li, Wenyu Cao, Liyan He, Huamao Zhou (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/PMC13452158.txt.
Description
Jingwen Yang and co-authors find in 2026 that ketamine shields net-like wraps around brain cells in mice worn down by long restraint stress. Those wraps, perineuronal nets, hug fast-firing brake cells and steer brain flex, and stress thins them. The team stressed mice, dosed some with ketamine, and counted wrap marks, brake cells, and immune cell marks in two brain zones.
Ketamine eased the mice's low-mood acts and saved wrap counts in both zones. It barely moved brake cell counts or the genes that build and cut the wraps. What fell hard was the count of active brain immune cells. The authors read the save as ketamine quieting those cells, which spares the wraps.
Catalog record
| CREATOR | Jingwen Yang, Ting Huang, Meng Wang, Yingrui Xu, Xuan Li, Changqi Li, Wenyu Cao, Liyan He, Huamao Zhou |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 51 KB |
| LICENSE | https://creativecommons.org/licenses/by/4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |