GSH-responsive self-assembled nanoplatform synergistically enhances cuproptosis through metabolic reprogramming and oxidative stress amplification
Bo Huang, Weijin Zhang, Yunjie Wang, Xian Luo, Wenda Wu, Rong Shen, Xiangquan Liu, Zhibo Zhang, Yi Gao, Yingying Wu, Fangwei Zeng, Yuan Huang, Jianyun Yu, Suxiao Wang, Ting Wu, Shengyu Wang, Shuitu Feng, Fanghong Luo · 2026
Read GSH-responsive self-assembled nanoplatform synergistically enhances cuproptosis through metabolic reprogramming and oxidative stress amplification by Bo Huang, Weijin Zhang, Yunjie Wang, Xian Luo, Wenda Wu, Rong Shen, Xiangquan Liu, Zhibo Zhang, Yi Gao, Yingying Wu, Fangwei Zeng, Yuan Huang, Jianyun Yu, Suxiao Wang, Ting Wu, Shengyu Wang, Shuitu Feng, Fanghong Luo (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/PMC13452149.txt.
Description
Bo Huang and a large team build in 2026 a nanoparticle that forces kidney cancer cells into a copper-driven death. That death path, cuproptosis, can beat drug resistance, yet copper carriers enter cells poorly and tumors resist. Their particle loads two cargoes: a gene that boosts a fuel gate in cell power plants, and a copper ferry drug.
Bonds in the particle snap in the tumor's chemical setting and drain a guard molecule, which fans cell rust. In dishes, the platform wiped out near all renal cancer cells and showed the death path's set marks. In mice, tumors shrank hard with no clear body-wide harm. The team frames the pairing as a fresh template.
Catalog record
| CREATOR | Bo Huang, Weijin Zhang, Yunjie Wang, Xian Luo, Wenda Wu, Rong Shen, Xiangquan Liu, Zhibo Zhang, Yi Gao, Yingying Wu, Fangwei Zeng, Yuan Huang, Jianyun Yu, Suxiao Wang, Ting Wu, Shengyu Wang, Shuitu Feng, Fanghong Luo |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 66 KB |
| LICENSE | https://creativecommons.org/licenses/by/4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |