PPARγ signalling pathway: molecular mechanisms and therapeutic potential in ligamentum flavum hypertrophy and lumbar spinal stenosis
Xue Chen, Chen Zhu, Shuhan Yang, Yuan Zeng, Bo Zhang, Chen Liang, Ye Tian, Tuanjiang Liu, Shanxi Wang · 2026
Read PPARγ signalling pathway: molecular mechanisms and therapeutic potential in ligamentum flavum hypertrophy and lumbar spinal stenosis by Xue Chen, Chen Zhu, Shuhan Yang, Yuan Zeng, Bo Zhang, Chen Liang, Ye Tian, Tuanjiang Liu, Shanxi Wang (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/PMC13452117.txt.
Description
Xue Chen and a large team review in 2026 a cell switch that may drive the ligament growth behind many cases of narrowed spine. The ligament, the flavum, thickens with age and squeezes the cord space, and no drug yet targets it. The switch, PPAR gamma, is a fat-sensing control that touches swelling, scar growth, blood vessel growth, and cell death.
The review walks each of those paths and the ways drugs might turn the switch. Direct proof in the ligament is still missing, the authors grant, yet the switch shows up in process after process that builds the thickening. They cast it as a prime lead for the first targeted drug work in this disease.
Catalog record
| CREATOR | Xue Chen, Chen Zhu, Shuhan Yang, Yuan Zeng, Bo Zhang, Chen Liang, Ye Tian, Tuanjiang Liu, Shanxi Wang |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 46392 |
| LICENSE | https://creativecommons.org/licenses/by/4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |