Inhibition of a Disintegrin and Metalloproteinase With Thrombospondin Type 1 Motif, Member 13 Activity by Peptidylarginine Deiminase IV Exacerbates Pancreatic Necrosis in Acute Pancreatitis
Wenjian Mao, Yiting Guan, Zongwen Zhang, Jing Zhou, Bo Ye, Gang Li, Jingzhu Zhang, Qi Yang, Shuang Peng, Wangsen Cao, Lin Gao, Weiqin Li, Lu Ke · 2026
Read Inhibition of a Disintegrin and Metalloproteinase With Thrombospondin Type 1 Motif, Member 13 Activity by Peptidylarginine Deiminase IV Exacerbates Pancreatic Necrosis in Acute Pancreatitis by Wenjian Mao, Yiting Guan, Zongwen Zhang, Jing Zhou, Bo Ye, Gang Li, Jingzhu Zhang, Qi Yang, Shuang Peng, Wangsen Cao, Lin Gao, Weiqin Li, Lu Ke (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/PMC13451909.txt.
Description
Wenjian Mao and a large team probe in 2026 a blood enzyme clash that worsens pancreas death in sudden pancreas attacks. A clot-trimming enzyme keeps a sticky blood factor in check, and white cell bursts free a second enzyme thought to block the trimmer. The team read both enzymes in 30 patients, then tested the link in dishes and in mice with made pancreas attacks.
Patients whose pancreas death passed a third of the organ showed low trimmer activity and high levels of the blocking enzyme. Blocking the blocker, adding the trimmer back, or breeding mice without either gene shifted the harm in line with the claim. The work names a fresh drug target for the worst pancreas attacks.
Catalog record
| CREATOR | Wenjian Mao, Yiting Guan, Zongwen Zhang, Jing Zhou, Bo Ye, Gang Li, Jingzhu Zhang, Qi Yang, Shuang Peng, Wangsen Cao, Lin Gao, Weiqin Li, Lu Ke |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 63500 |
| LICENSE | https://creativecommons.org/licenses/by/4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |