Single‐Cell RNA Sequencing Revealed the Role of Interferon‐Gamma Related Genes in Primary Sjögren's Syndrome
Lei Shi, Tian‐chi Wei, Jing Zhang · 2026
Read Single‐Cell RNA Sequencing Revealed the Role of Interferon‐Gamma Related Genes in Primary Sjögren's Syndrome by Lei Shi, Tian‐chi Wei, Jing Zhang (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/PMC13451524.txt.
Description
Shi, Wei, and Zhang hunt for genes tied to interferon gamma, an immune signal that runs awry in primary Sjögren's syndrome. In this long term disease the immune system attacks the glands that make tears and saliva. Their 2026 study mines public gene data from patient blood. It adds single cell sequencing, which reads genes cell by cell, and checks the results with a lab test on patient samples.
Four genes stood out: HERC6, IL15, CD58, and PTGS2, and a model built on them sorted patients from healthy people with high accuracy. Immune profiling showed a broadly disturbed cell mix in patients. Single cell maps pointed to macrophages, large immune cells that engulf debris, as central actors with altered development paths and stronger signaling to other cells. Lab checks confirmed that three of the four genes run higher in patients, backing them as candidate markers and drug targets.
Catalog record
| CREATOR | Lei Shi, Tian‐chi Wei, Jing Zhang |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 71 KB |
| LICENSE | https://creativecommons.org/licenses/by/4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |