Upadacitinib for recalcitrant extragenital morphea and lichen sclerosus overlap: A case report
Taha Rasul, Christian E Hemmerich, Benjamin Cooper, Lily Tehrani, Karthik Krishnamurthy · 2026
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Description
Taha Rasul and co-authors report a 2026 case where a drug aimed at immune signaling eased a hard mix of two hardening skin diseases. The overlap of morphea and lichen sclerosus outside the genital area is rare and can spread widely. Their patient, a woman aged 67, had sore, tight plaques across her trunk, sides, and upper thighs.
Biopsies confirmed the overlap, which covered over a quarter of her skin and limited her movement. Creams, light therapy, and several whole-body drugs had failed or were not tolerated. The new drug, upadacitinib, blocks a Janus kinase path, and her skin improved markedly once she started it, a result the team offers as a lead for others stuck without options.
Catalog record
| CREATOR | Taha Rasul, Christian E Hemmerich, Benjamin Cooper, Lily Tehrani, Karthik Krishnamurthy |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 10629 |
| LICENSE | https://creativecommons.org/licenses/by/4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |