A gE/gI/US9-triple deletion inactivated vaccine provides complete protection against emerging PRV variant infection
Yuchuan Yang, Ziyun Xie, Heteng Zhang, Zhihua Yang, Baishi Lei, Kuan Zhao, Yunhang Zhang, Wanzhe Yuan, Jie Tong, Wuchao Zhang · 2026
Read A gE/gI/US9-triple deletion inactivated vaccine provides complete protection against emerging PRV variant infection by Yuchuan Yang, Ziyun Xie, Heteng Zhang, Zhihua Yang, Baishi Lei, Kuan Zhao, Yunhang Zhang, Wanzhe Yuan, Jie Tong, Wuchao Zhang (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-13450462.txt.
Description
Yuchuan Yang and colleagues developed a triple-deletion inactivated vaccine in 2026 against emerging pseudorabies virus variants in pigs. Since 2011, variant strains in China have evaded conventional vaccines, causing heavy losses. The team used CRISPR-based editing to knock out three viral genes, gE, gI, and US9, and built inactivated vaccines from the mutants.
All mutants grew like the parent virus but formed smaller plaques, and none reverted after twenty passages. In animals, the triple-deletion mutant triggered stronger neutralizing antibodies, more Th1 cytokines, and more lymphocyte growth, without shifting Th2 cytokines. All immunized groups were then tested against variant challenge, with the triple-deletion vaccine giving complete protection in the reported tests. Pig producers gain a candidate vaccine matched to current variants.
Catalog record
| CREATOR | Yuchuan Yang, Ziyun Xie, Heteng Zhang, Zhihua Yang, Baishi Lei, Kuan Zhao, Yunhang Zhang, Wanzhe Yuan, Jie Tong, Wuchao Zhang |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 45 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |