Deoxycholic acid impairs mitochondrial fitness and suppresses mitophagy through Parkin ubiquitination driving CD8+ T cell Exhaustion in Colorectal Cancer
Yang Gao, Jiaxin Wang, Shihui Lai, Mingwei Li, Jiaqi Shi, Xianjun Li, Ying Guo, Sainan Ma, Xinxin Wang, Shule Zhang, Tianyu He, Yu Hong, Shuang Li, Caiqi Liu, Lijuan Cao, Haiping Hao, Chujie Ding · 2026
Read Deoxycholic acid impairs mitochondrial fitness and suppresses mitophagy through Parkin ubiquitination driving CD8+ T cell Exhaustion in Colorectal Cancer by Yang Gao, Jiaxin Wang, Shihui Lai, Mingwei Li, Jiaqi Shi, Xianjun Li, Ying Guo, Sainan Ma, Xinxin Wang, Shule Zhang, Tianyu He, Yu Hong, Shuang Li, Caiqi Liu, Lijuan Cao, Haiping Hao, Chujie Ding (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/PMC13450440.txt.
Description
Yang Gao and a large team identify in 2026 a metabolic reason some colorectal cancers shrug off immunotherapy: a bile acid that wrecks the mitochondria of killer T cells. Tumors bathed in high bile acid levels answered anti-PD-1 treatment poorly in both patient data and mouse models, with fewer and weaker tumor-infiltrating CD8 cells. Profiling the bile acids singled out deoxycholic acid as the culprit species.
In laboratory and animal work, that acid suppressed the T cells' killing functions and pushed them into terminal exhaustion. Inside the cells it throttled energy production through oxidative phosphorylation and flooded mitochondria with reactive oxygen. It also marked Parkin, the protein that orders disposal of damaged mitochondria, for destruction, so broken power plants piled up. A drug that reactivates that cleanup, urolithin A, reversed the defects and restored anti-PD-1 power in mice, offering a metabolic rescue route.
Catalog record
| CREATOR | Yang Gao, Jiaxin Wang, Shihui Lai, Mingwei Li, Jiaqi Shi, Xianjun Li, Ying Guo, Sainan Ma, Xinxin Wang, Shule Zhang, Tianyu He, Yu Hong, Shuang Li, Caiqi Liu, Lijuan Cao, Haiping Hao, Chujie Ding |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 88 KB |
| LICENSE | https://creativecommons.org/licenses/by/4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |