From LNPs to hybrid nanocarriers: development, challenges and redesign of non-viral gene delivery
Wenlin Wu, Zhigong Wei, Xingchen Peng · 2026
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Description
Wenlin Wu and colleagues reviewed non-viral gene delivery in 2026, from lipid nanoparticles to hybrid carriers. Gene therapy can treat disease at its molecular root, but success depends on safe and efficient delivery. Viral vectors deliver well yet raise safety worries, while non-viral options offer safety, tunable design, larger cargo, and scalable production.
The review covers five major classes, including lipid nanoparticles, polyplexes, lipoplexes, and exosomes, plus hybrids that mix their strengths. For each platform it summarizes structure, delivery mechanism, uses, and barriers to clinical translation. A unified structure-function-application frame helps readers compare options. The piece serves as a map for choosing and improving carriers that must reach the right cells without viral risks.
Catalog record
| CREATOR | Wenlin Wu, Zhigong Wei, Xingchen Peng |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 122 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |