Neuronal VPS13A depletion links diacylglycerol PKC signaling and synaptic spines
Gisela Besa-Selva, Esther García-García, Alba Ramón-Lainez, Georgia Escaramis, Pol Garcia-Segura, Cristina Malagelada, Eulàlia Martí, Jordi Alberch, Mercè Masana, Manuel J Rodríguez · 2026
Read Neuronal VPS13A depletion links diacylglycerol PKC signaling and synaptic spines by Gisela Besa-Selva, Esther García-García, Alba Ramón-Lainez, Georgia Escaramis, Pol Garcia-Segura, Cristina Malagelada, Eulàlia Martí, Jordi Alberch, Mercè Masana, Manuel J Rodríguez (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-13450030.txt.
Description
Gisela Besa-Selva and colleagues studied a rare movement disorder in mice in 2026, tracing how loss of one protein disturbs nerve cells. Mutations in the VPS13A gene stop the protein from being made and cause chorea-acanthocytosis, an inherited disorder that harms movement and nerves. The protein moves lipids between membranes, so faulty lipid spread was a prime suspect.
Silencing the gene in mouse neurons raised several diacylglycerol fats and shifted protein kinase C signaling, lowering one form while raising its activated state. Blocking that kinase reversed odd cell shapes and restored the density of synaptic spines, the tiny posts where neurons connect. The work links a lipid-transfer fault to visible nerve damage and names a pathway that drugs might one day target.
Catalog record
| CREATOR | Gisela Besa-Selva, Esther García-García, Alba Ramón-Lainez, Georgia Escaramis, Pol Garcia-Segura, Cristina Malagelada, Eulàlia Martí, Jordi Alberch, Mercè Masana, Manuel J Rodríguez |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 56 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |