Clinical and therapeutic implications of HLAB51-negative status in Pediatric Behçet’s Disease
Matheus Santos França, Thales Queiroz Souza, Ricardo Nóbrega Machado, Vinicius Campos Matias, Verena Andrade Balbi, Nadia Emi Aikawa, Katia Tomie Kozu, Clovis Artur Silva, Lucia Maria de Arruda Campos, Adriana Maluf Elias · 2026
Read Clinical and therapeutic implications of HLAB51-negative status in Pediatric Behçet’s Disease by Matheus Santos França, Thales Queiroz Souza, Ricardo Nóbrega Machado, Vinicius Campos Matias, Verena Andrade Balbi, Nadia Emi Aikawa, Katia Tomie Kozu, Clovis Artur Silva, Lucia Maria de Arruda Campos, Adriana Maluf Elias (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/PMC13449806.txt.
Description
Matheus Santos França and colleagues write in 2026 about children and teenagers with Behçet disease who lack the genetic marker most associated with it, HLA-B51. The disease is an inflammatory disorder first described in 1937. It clusters along the old Silk Road and strikes hardest in the Middle and Far East, where the marker is common and tied to severe cases. Childhood disease is harder to pin down because symptoms arrive piecemeal, so classification criteria exist alongside judgment.
Pediatric data from Latin America are scarce, so the team analyzed 32 patients at a Brazilian tertiary rheumatology center, a multiethnic setting where 15.5 percent of healthy people carry the marker. Median age at diagnosis was four and a half years, half the patients were female, and most declared white ethnicity. Their letter investigates what HLA patterns, including B51-negative status, mean for how these children's disease presents and should be treated.
Catalog record
| CREATOR | Matheus Santos França, Thales Queiroz Souza, Ricardo Nóbrega Machado, Vinicius Campos Matias, Verena Andrade Balbi, Nadia Emi Aikawa, Katia Tomie Kozu, Clovis Artur Silva, Lucia Maria de Arruda Campos, Adriana Maluf Elias |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 9 KB |
| LICENSE | https://creativecommons.org/licenses/by/4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |