Safety of transcutaneous electrical stimulation potentiating recovery in acute spinal cord injury syndromes: a trial protocol
Anastasia Keller, Prakruthi Amar Kumar, Xuan Bradfield, Debra Hemmerle, J. Russell Huie, H. E. Hinson, Rajiv Saigal · 2026
Read Safety of transcutaneous electrical stimulation potentiating recovery in acute spinal cord injury syndromes: a trial protocol by Anastasia Keller, Prakruthi Amar Kumar, Xuan Bradfield, Debra Hemmerle, J. Russell Huie, H. E. Hinson, Rajiv Saigal (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/PMC13449234.txt.
Description
Anastasia Keller and co-authors publish in 2026 the protocol for STEP-RAISE, an early-phase trial of electrical stimulation for acute spinal cord injury. No proven therapy yet protects the cord in the first hours after trauma, when lasting paralysis is often sealed. Stimulation through skin electrodes over the lower back helps some patients with chronic injury, so the team will test starting within 72 hours of injury in moderate-to-severe cases, using the ARC-Ex device.
Phase 1 enrolls five participants for safety work, checking blood pressure stability, cord perfusion, and skin reactions. Phase 2 then randomizes ten participants in a triple-blinded, placebo-controlled design. Recovery is tracked with the standard neurological examination, muscle recordings, patient reports, and blood and spinal fluid markers of nerve and support-cell injury, through six months. The trial, registered as NCT07090473, is sized to estimate effects and shape a larger study.
Catalog record
| CREATOR | Anastasia Keller, Prakruthi Amar Kumar, Xuan Bradfield, Debra Hemmerle, J. Russell Huie, H. E. Hinson, Rajiv Saigal |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 42121 |
| LICENSE | https://creativecommons.org/licenses/by/4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |