Multi-metric evaluations of acute psychedelic effects on fMRI brain entropy
Drummond E-Wen McCulloch, Anders Stevnhoved Olsen, Brice Ozenne, Kristian Larsen, Dea Siggaard Stenbæk, Sophia Armand, Martin Korsbak Madsen, Gitte Moos Knudsen, Patrick MacDonald Fisher · 2026
Read Multi-metric evaluations of acute psychedelic effects on fMRI brain entropy by Drummond E-Wen McCulloch, Anders Stevnhoved Olsen, Brice Ozenne, Kristian Larsen, Dea Siggaard Stenbæk, Sophia Armand, Martin Korsbak Madsen, Gitte Moos Knudsen, Patrick MacDonald Fisher (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/PMC13448839.txt.
Description
Drummond McCulloch and colleagues test in 2026 whether the many published measures of brain entropy actually agree when a psychedelic drug is given. Theory holds that psychedelics raise the entropy, or disorder, of brain activity. Thirteen earlier studies each used a different measure, so the team applied the full set to one shared dataset.
Their data came from 28 healthy volunteers with 121 brain scans taken before and after psilocybin. Five measures rose consistently with drug effects, including Shannon entropy of the spatial pattern and short-scale sample entropy. Eight of fourteen measures showed no dependable effect, and the rest behaved inconsistently. The measures also correlated weakly with each other, leading the authors to conclude that brain entropy is not one single thing these tools all capture.
Catalog record
| CREATOR | Drummond E-Wen McCulloch, Anders Stevnhoved Olsen, Brice Ozenne, Kristian Larsen, Dea Siggaard Stenbæk, Sophia Armand, Martin Korsbak Madsen, Gitte Moos Knudsen, Patrick MacDonald Fisher |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 79768 |
| LICENSE | https://creativecommons.org/licenses/by/4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |