Efficacy of orthokeratology combined with atropine versus orthokeratology alone for myopia control in children: a meta-analysis
Yuchan Li, Meichao Yi, Bing Liu · 2026
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Description
Yuchan Li, Meichao Yi, and Bing Liu pool in 2026 the trial evidence on combining overnight corneal lenses with atropine drops to slow childhood nearsightedness. Their meta-analysis gathered 18 randomized trials covering 1,669 children. The comparison was orthokeratology lenses alone against the same lenses plus atropine, a drug that relaxes the eye's focusing muscle.
Across trials, the combined treatment slowed eye elongation more, with a standardized difference of −0.66, and reshaped the cornea more strongly. It gave no clear advantage in unaided vision or in the thickness of the tear film's oily layer. Children on the combination also had wider pupils and weaker focusing power, known effects of atropine that parents and clinicians must weigh against the slower growth of the eye.
Catalog record
| CREATOR | Yuchan Li, Meichao Yi, Bing Liu |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 32 KB |
| LICENSE | https://creativecommons.org/licenses/by/4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |