TLSB-16 GENOMIC AND CLINICAL PREDICTORS OF SURVIVAL FOLLOWING SURGICAL RESECTION OF BRAIN METASTASES
Neslihan Nisa Gecici, Ahmed Habib, Walaa Hamza, Maged T Ghoche, Rivka R Colen, Kalil G Abdullah, Pascal O Zinn · 2026
Read TLSB-16 GENOMIC AND CLINICAL PREDICTORS OF SURVIVAL FOLLOWING SURGICAL RESECTION OF BRAIN METASTASES by Neslihan Nisa Gecici, Ahmed Habib, Walaa Hamza, Maged T Ghoche, Rivka R Colen, Kalil G Abdullah, Pascal O Zinn (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/PMC13448275.txt.
Description
Gecici and colleagues at the University of Pittsburgh Medical Center studied which clinical and genetic features predict survival after surgery for cancer spread to the brain. Their 2026 conference report covers 228 patients whose tumors were removed, most often cancers that began in the lung, breast, urinary tract, gut, or skin. Survival after such surgery varies widely, and genetic predictors remain poorly understood.
Gecici profiled tumor genes in about three fifths of the patients and ranked predictors using forest models and survival analysis. TP53 gene changes were most common, followed by KRAS changes and losses near CDKN2A and CDKN2B. Patients in good physical condition before surgery lived far longer than frail patients, with median survival more than three times as long. Extra KRAS copies and poor condition predicted worse survival, while systemic drug treatment after surgery strongly predicted longer life, supporting combined genetic and clinical risk scoring.
Catalog record
| CREATOR | Neslihan Nisa Gecici, Ahmed Habib, Walaa Hamza, Maged T Ghoche, Rivka R Colen, Kalil G Abdullah, Pascal O Zinn |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 2 KB |
| LICENSE | https://creativecommons.org/licenses/by/4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |