Circular RNA circTrpc6-induced tau phosphorylation contributes to neuronal injury and cognitive decline via miR-485-5p/eIF4E axis in senescence-accelerated mouse prone 8 mice
Jin-Lan Huang, Qiu-Qing Yan, Yan-Bin Guo, Yu-Xuan Du, Ling-Ling Liu, Xiao-Jing Sun, Chao Yu, Deng-Pan Wu · 2026
Read Circular RNA circTrpc6-induced tau phosphorylation contributes to neuronal injury and cognitive decline via miR-485-5p/eIF4E axis in senescence-accelerated mouse prone 8 mice by Jin-Lan Huang, Qiu-Qing Yan, Yan-Bin Guo, Yu-Xuan Du, Ling-Ling Liu, Xiao-Jing Sun, Chao Yu, Deng-Pan Wu (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-13447473.txt.
Description
Jin-Lan Huang and coauthors report a 2026 study linking the loop RNA circTrpc6 to tau phosphate tagging and thinking decline in fast-aging mice. The team found the RNA plentiful in memory-center and brain-surface neurons and raised in aged-prone mouse memory center, then tested knockdown and overdrive in cells and mice.
Muting circTrpc6 reduced tau phosphate tagging and clumping, eased nerve and junction injury, and lifted thinking, while overdrive deepened tau damage. The RNA acts by sponging miR-485-5p to raise eIF4E and its link with tau courier RNA. The axis marks circTrpc6 as a hopeful treatment target for tau-driven decline.
Catalog record
| CREATOR | Jin-Lan Huang, Qiu-Qing Yan, Yan-Bin Guo, Yu-Xuan Du, Ling-Ling Liu, Xiao-Jing Sun, Chao Yu, Deng-Pan Wu |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 57 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |