Multi-ancestry genome-wide association analyses provide insights into the genetic basis of Hashimoto’s thyroiditis
Melissa N. Bujnis, Rosalie B. T. M. Sterenborg, Yong Li, Bjørn Olav Åsvold, Luka Brčić, Vesna Boraska Perica, Anav Babbar, Joshua C. Denny, Lars G. Fritsche, Masahiro Kanai, Ilze Konrade, Graham Leese, Eirini Marouli, Andres Metspalu, Marta R. Moksnes, Bhramar Mukherjee, Yukinori Okada, Colin N. A. Palmer, Areti Papadopoulou, Raitis Peculis, Vita Rovite, Peter J. Sauer, Enrique Soto-Pedre, Sundararajan Srinivasan, Inga Steinbrenner, Maris Teder-Laving, Bin Wang, Antoine Weihs, Chenjie Zeng, Jin Zhou, Yukinori Okada, Yukinori Okada, XiCheng Song, Lynn B. Jorde, Marco Medici, Alexander Teumer · 2026
Read Multi-ancestry genome-wide association analyses provide insights into the genetic basis of Hashimoto’s thyroiditis by Melissa N. Bujnis, Rosalie B. T. M. Sterenborg, Yong Li, Bjørn Olav Åsvold, Luka Brčić, Vesna Boraska Perica, Anav Babbar, Joshua C. Denny, Lars G. Fritsche, Masahiro Kanai, Ilze Konrade, Graham Leese, Eirini Marouli, Andres Metspalu, Marta R. Moksnes, Bhramar Mukherjee, Yukinori Okada, Colin N. A. Palmer, Areti Papadopoulou, Raitis Peculis, Vita Rovite, Peter J. Sauer, Enrique Soto-Pedre, Sundararajan Srinivasan, Inga Steinbrenner, Maris Teder-Laving, Bin Wang, Antoine Weihs, Chenjie Zeng, Jin Zhou, Yukinori Okada, Yukinori Okada, XiCheng Song, Lynn B. Jorde, Marco Medici, Alexander Teumer (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/PMC13447099.txt.
Description
Melissa Bujnis leads a large team reporting 2026 genome-wide results for Hashimoto's thyroiditis, where the immune system attacks the thyroid gland. Earlier studies often used loose case definitions and mostly European samples. Here the authors combined ten cohorts across ancestries, with a strict definition of who counted as a case.
Nearly forty-nine thousand cases were compared with more than a million controls. The scan found many linked genetic regions, including new loci never tied to low thyroid function before. Follow-up work pointed to immune cells and the spleen, plus shared signals in thyroid tissue itself. Separate analyses also linked the condition to heart-related traits and hormone levels, giving researchers a sharper map for future work on causes and treatment.
Catalog record
| CREATOR | Melissa N. Bujnis, Rosalie B. T. M. Sterenborg, Yong Li, Bjørn Olav Åsvold, Luka Brčić, Vesna Boraska Perica, Anav Babbar, Joshua C. Denny, Lars G. Fritsche, Masahiro Kanai, Ilze Konrade, Graham Leese, Eirini Marouli, Andres Metspalu, Marta R. Moksnes, Bhramar Mukherjee, Yukinori Okada, Colin N. A. Palmer, Areti Papadopoulou, Raitis Peculis, Vita Rovite, Peter J. Sauer, Enrique Soto-Pedre, Sundararajan Srinivasan, Inga Steinbrenner, Maris Teder-Laving, Bin Wang, Antoine Weihs, Chenjie Zeng, Jin Zhou, Yukinori Okada, Yukinori Okada, XiCheng Song, Lynn B. Jorde, Marco Medici, Alexander Teumer |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 67 KB |
| LICENSE | https://creativecommons.org/licenses/by/4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |