Making base editing accessible: Evaluating computational workflows for ABE-mediated gene knockout
James Williamson, Aidin Kazemizadeh, Joanna Jacków-Malinowska · 2026
Read Making base editing accessible: Evaluating computational workflows for ABE-mediated gene knockout by James Williamson, Aidin Kazemizadeh, Joanna Jacków-Malinowska (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/PMC13446179.txt.
Description
James Williamson and colleagues weigh a new computing workflow that aims to make base editing, a precise gene tweaking method, easier for labs to plan, in a 2026 commentary. Base editors swap single DNA letters without cutting both strands, which trims stray damage. Yet many labs still default to older CRISPR cutting, in part for want of friendly design tools.
The workflow under review, from Eaton and co-workers, joins existing design tools with a fresh analysis platform for knockout experiments with adenine base editors. It walks users through editor choice, guide design, delivery, and proof checks, with immune targets as the worked case. The commentary sets the tool in context and asks how far such pipelines can widen careful use of base editing.
Catalog record
| CREATOR | James Williamson, Aidin Kazemizadeh, Joanna Jacków-Malinowska |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 6 KB |
| LICENSE | https://creativecommons.org/licenses/by/4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |