Immortalization of Adipose‐Derived Stromal Cells From Japanese Black Cattle
Rei Sasaki, Hanami Matsukura, Ryo Meguro, Lanlan Bai, Ken Sawai, Eriko Sugano, Hiroshi Tomita, Tohru Kiyono, Tomokazu Fukuda · 2026
Read Immortalization of Adipose‐Derived Stromal Cells From Japanese Black Cattle by Rei Sasaki, Hanami Matsukura, Ryo Meguro, Lanlan Bai, Ken Sawai, Eriko Sugano, Hiroshi Tomita, Tohru Kiyono, Tomokazu Fukuda (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/PMC13445999.txt.
Description
Sasaki and colleagues create an immortalized cell line from premium beef cattle in this 2026 study. Japanese Black cattle are prized for beef aroma, tenderness, and flavor, traits rooted in fat tissue biology that is still poorly understood. Fat-derived stromal cells can mature into fat cells for laboratory study, but ordinary primary cells stop dividing quickly and vary between animals, limiting long experiments.
Using a method called K4DT, the team inserted three genes that together override the normal cell-division limit, including a telomere-maintaining enzyme. The resulting bovine cells kept dividing stably over long-term culture, a key test of true immortalization. Crucially, the cells retained the ability to differentiate into fat cells when prompted. So the line can serve as a reproducible model. It suits studying how this breed builds its distinctive fat.
Catalog record
| CREATOR | Rei Sasaki, Hanami Matsukura, Ryo Meguro, Lanlan Bai, Ken Sawai, Eriko Sugano, Hiroshi Tomita, Tohru Kiyono, Tomokazu Fukuda |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 32 KB |
| LICENSE | https://creativecommons.org/licenses/by/4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |