ELYS promotes hepatocellular carcinoma stemness by activating a FOXO6-NUP205 transcriptional module downstream of PI3K/AKT to drive Hedgehog signaling
Xin Chen, Qing Zhang, Fen Xie, Huilan Zhai, Chuanhong Li, Weifeng Zhou, Nuobei Zhang · 2026
Read ELYS promotes hepatocellular carcinoma stemness by activating a FOXO6-NUP205 transcriptional module downstream of PI3K/AKT to drive Hedgehog signaling by Xin Chen, Qing Zhang, Fen Xie, Huilan Zhai, Chuanhong Li, Weifeng Zhou, Nuobei Zhang (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-13445670.txt.
Description
Xin Chen and coauthors define a 2026 cancer mechanism by which the nuclear pore protein ELYS drives liver cancer stemness and spread. The team combined gene sequencing, cell assays, pathway blockers, reporter and binding tests, mouse grafts, and clinical samples. Together these mapped a chain from ELYS through PI3K-AKT to a FOXO6-NUP205 module and Hedgehog signaling.
ELYS pushed a key Hedgehog factor into the nucleus, raised its effectors, and promoted tumor growth and lung metastasis in mice. Patient tumors overexpressed all three axis members alongside advanced disease and poor survival. Blocking the FOXO6 step erased ELYS-driven effects in cells. The axis offers a therapeutic target for liver cancer stemness, pending drug development.
Catalog record
| CREATOR | Xin Chen, Qing Zhang, Fen Xie, Huilan Zhai, Chuanhong Li, Weifeng Zhou, Nuobei Zhang |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 83 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |