A single-cell transcriptomic atlas of peripheral blood immune cells spanning progressive canine leishmaniosis
Danielle P. Uhl, Daniel J. Holbrook, Max C. Waugh, Shoumit Dey, Najmeeyah Brown, Karen I. Cyndari, Jacob J. Oleson, Paul M. Kaye, Christine A. Petersen · 2026
Read A single-cell transcriptomic atlas of peripheral blood immune cells spanning progressive canine leishmaniosis by Danielle P. Uhl, Daniel J. Holbrook, Max C. Waugh, Shoumit Dey, Najmeeyah Brown, Karen I. Cyndari, Jacob J. Oleson, Paul M. Kaye, Christine A. Petersen (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/PMC13444607.txt.
Description
Danielle P. Uhl and colleagues present a single-cell atlas of blood immune cells in dogs at each stage of leishmaniosis, a parasite disease spread by sand flies. Published in 2026, the work maps dogs with no infection beside dogs with mild through severe illness from Leishmania infantum. Dogs matter here because they carry the parasite and pass it on to people, so their illness mirrors a wider public health risk.
The team used single-cell RNA sequencing to track how cell types shift as disease grows worse. Blood moved from a lymphoid-heavy mix toward a myeloid-heavy one, helper T cells showed growing signs of exhaustion, and monocytes took on more inflamed states. Readers gain a shared reference, named the LeishDog Atlas, for comparing immune change across stages and for later work on treatment.
Catalog record
| CREATOR | Danielle P. Uhl, Daniel J. Holbrook, Max C. Waugh, Shoumit Dey, Najmeeyah Brown, Karen I. Cyndari, Jacob J. Oleson, Paul M. Kaye, Christine A. Petersen |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 80781 |
| LICENSE | https://creativecommons.org/licenses/by/4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |