Tumor-infiltrating B cells inhibit nasopharyngeal carcinoma metastasis
Jing Cai, Xiangzhou Tan, Xinglong Liu, Juan Feng, Xiangying Deng, Lin Zhao · 2026
Read Tumor-infiltrating B cells inhibit nasopharyngeal carcinoma metastasis by Jing Cai, Xiangzhou Tan, Xinglong Liu, Juan Feng, Xiangying Deng, Lin Zhao (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-13444244.txt.
Description
Jing Cai and colleagues report a 2026 study showing that tumor-infiltrating B cells help block spread in nasopharyngeal carcinoma, a cancer whose advanced cases fail mainly through distant metastasis. Combining single-cell sequencing with multiplex imaging, the team compared B cell patterns in metastatic and non-metastatic tumors, then tested function in cells and mice.
B cells crowded non-metastatic tumors and built complete tertiary lymphoid structures absent in metastatic disease. In lab and humanized mouse tests, these B cells and their secretions curbed growth, migration, and transition programs while triggering cell death, and removing B cells sped progression. Two signals, IL-12 and CXCL13, drove the defense, supporting B cell and lymphoid-structure immunotherapy designs.
Catalog record
| CREATOR | Jing Cai, Xiangzhou Tan, Xinglong Liu, Juan Feng, Xiangying Deng, Lin Zhao |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 50 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |