Effect of respiratory acid-base balance on rocuronium-induced neuromuscular blockade and sugammadex-induced reversal in rat phrenic nerve hemidiaphragm
Yong Beom Kim, Chun Gon Park, Jae-Moon Choi, Hey Ran Choi, Junyong In, Boo Keun Son, Hong Seuk Yang · 2026
Read Effect of respiratory acid-base balance on rocuronium-induced neuromuscular blockade and sugammadex-induced reversal in rat phrenic nerve hemidiaphragm by Yong Beom Kim, Chun Gon Park, Jae-Moon Choi, Hey Ran Choi, Junyong In, Boo Keun Son, Hong Seuk Yang (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-13444183.txt.
Description
Yong Beom Kim and colleagues test a 2026 ex vivo rat model of how breathing-related acid-base shifts change muscle blockade by rocuronium and its reversal by sugammadex, a balance anesthetists manage daily. Diaphragm specimens from 30 rats were split into control, alkalosis, and acidosis gas mixtures and stimulated in a train-of-four pattern.
Only acidosis shifted the dose-response curves for twitch strength and train-of-four ratio against alkalosis, and recovery paths differed across groups. Total drug doses also differed between control and acidosis groups and between acidosis and alkalosis groups. The authors caution that carbon dioxide shifts may matter clinically, though group differences were not uniformly decisive.
Catalog record
| CREATOR | Yong Beom Kim, Chun Gon Park, Jae-Moon Choi, Hey Ran Choi, Junyong In, Boo Keun Son, Hong Seuk Yang |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 21 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |