Sustained-release local anesthetics: advances in drug delivery systems for prolonged postoperative analgesia
Seok Kyeong Oh, Sang Hyun Hong, Jung-Woo Shim · 2026
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Description
Oh, Hong, and Shim reviewed in 2026 slow-release local anaesthetics, designed to stretch pain relief after surgery from a single injection. Standard numbing drugs wear off within hours, and pump catheters that top them up bring device hassles. Longer relief supports modern recovery plans that get patients moving early. Three carrier families lead the field.
Oh describes fat-bubble preparations that leak drug slowly at the injection site. Polymer systems pair the drug with anti-inflammatory agents to calm the tissue. Gel networks hold and release the drug while limiting spread into the blood. Gains are real but uneven: early burst release, variable timing, high cost, and thin trial proof slow adoption. The authors expect these systems to grow into catheter-free pain control as delivery tech and validation improve.
Catalog record
| CREATOR | Seok Kyeong Oh, Sang Hyun Hong, Jung-Woo Shim |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 32 KB |
| LICENSE | https://creativecommons.org/licenses/by/4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |