Pathogen-specific immune responses might underlie divergent outcomes of coronavirus and influenza infection in the natural porcine host
Ehsan Sedaghat-Rostami, Liu Yang, Ashutosh Vats, Basudev Paudyal, Emily Briggs, Brigid Veronica Carr, Graham Freimanis, Ines Ruedas-Torres, Tim Downing, Christine Rollier, Katherine Marougka, Cornelis A. M. De Haan, Jai Mehat, Roberto La Ragione, Andrew Muir, Arianne C. Richard, Kristien Van Reeth, · 2026
Read Pathogen-specific immune responses might underlie divergent outcomes of coronavirus and influenza infection in the natural porcine host by Ehsan Sedaghat-Rostami, Liu Yang, Ashutosh Vats, Basudev Paudyal, Emily Briggs, Brigid Veronica Carr, Graham Freimanis, Ines Ruedas-Torres, Tim Downing, Christine Rollier, Katherine Marougka, Cornelis A. M. De Haan, Jai Mehat, Roberto La Ragione, Andrew Muir, Arianne C. Richard, Kristien Van Reeth, (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-13444145.txt.
Description
Ehsan Sedaghat-Rostami and coauthors compare a 2026 pig study of porcine coronavirus and H1N1 flu, two lung threats whose courses differ and may reveal how host defense shapes outcome. Using pigs as a large-animal model, the team tracked viral load, shedding, immune protein and T cell levels, B cell memory, and nasal germs.
The virus drove higher viral loads, longer shedding, stronger systemic and mucosal T cell firing, and memory B cell growth. Flu set off faster blocking antibodies, stronger follicular helper and germinal center action, and broader early nasal range. Shared interferon genes opened both cases before stromal and vessel pathways split. Pigs thus offer a strong side-by-side model for lung virus research.
Catalog record
| CREATOR | Ehsan Sedaghat-Rostami, Liu Yang, Ashutosh Vats, Basudev Paudyal, Emily Briggs, Brigid Veronica Carr, Graham Freimanis, Ines Ruedas-Torres, Tim Downing, Christine Rollier, Katherine Marougka, Cornelis A. M. De Haan, Jai Mehat, Roberto La Ragione, Andrew Muir, Arianne C. Richard, Kristien Van Reeth, |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 91 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |